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NEUROPATHIC PAIN

Neuropathic mechanisms as the source of dry eye pain should be considered when dry eye symptoms persist despite appropriate treatment. In such cases central nervous system changes with pain attributed to centralized mechanisms should be targeted with such treatment as Gabapentin and/or Effexor or Cymbalta, other.

Neuropathic ocular pain: an important yet underevaluated feature of dry eye

Vitamin B12 deficiency evaluation and treatment in severe dry eye disease with neuropathic ocular pain